Effects of strength training for prostate cancer patients during androgen deprivation therapy

Abstract

Androgen deprivation therapy (ADT) increases survival rates among prostate cancer (PCa) patients with locally advanced disease, but is associated with side effects that may impair daily function through negative effects on muscle tissue. Although strength training may counteract several side effects induced by ADT, additional randomized controlled trials are needed to expand this knowledge. So far no studies have investigated the effects of strength training during long-­‐term ADT on the muscle cellular level.

Paper I: Thorsen L., Nilsen T.S., Raastad T., Courneya K.S., Skovlund E,. Fosså S.D.: A randomized controlled trial on the effectiveness of strength training on clinical and muscle cellular outcomes in patients with prostate cancer during androgen deprivation therapy: rationale and design. BMC Cancer 2012, 12(1):123

Paper II: Nilsen T.S., Raastad T., Skovlund E., Courneya K.S., Langberg C.W., Lilleby W., Fosså S.D., Thorsen L.: Effects of strength training on body composition, physical functioning and quality of life in prostate cancer patients during androgen deprivation therapy. Accepted by ACTA Oncologica.

Paper III: Nilsen T.S., Thorsen L., Fosså S.D., Wiig M., Kirkegaard C., Skovlund E., Benestad H.B., Raastad T.: Effect of strength training on muscle cellular variables during androgen deprivation for prostate cancer: a randomised trial. Accepted by Scandinavian Journal of Medicine and Science in sports.

Paper IV: Tatt ut av filen i Brage p.g.a. copyright-restriksjoner. / Not in the file in Brage because of copyright issues.