dc.contributor.author | Lai, Yu-Chiang | |
dc.date.accessioned | 2010-04-12T11:15:14Z | |
dc.date.issued | 2010-04 | |
dc.identifier | Seksjon for fysisk prestasjonsevne / Department of Physical Performance | |
dc.identifier.isbn | 978-82-502-0436-2 | |
dc.identifier.uri | http://hdl.handle.net/11250/171297 | |
dc.description | Avhandling (doktorgrad) – Norges idrettshøgskole, 2010. | en |
dc.description.abstract | The present thesis is based on 4 papers which have investigated contraction- and
insulin-mediated regulations of glucose uptake and GS activation in skeletal muscles
with different glycogen contents. The level of glycogen content in skeletal muscle has
a strong effect on the regulation of glucose metabolism. In the present thesis, we have
shown that low glycogen content strongly increased glucose uptake in epitrochlearis
muscle either under insulin and contraction stimulation alone or in combination.
GLUT4 content was increased in epitrochlearis muscle with low glycogen content
which can contribute the increased glucose uptake. Although insulin-stimulated PKB
phosphorylation and contraction-stimulated AMPK activation were highest in muscle
with low glycogen content, AS160/TBC1D1 phosphorylation was not elevated
correspondingly, suggesting that these key signalling molecules do not determine the
rate of glucose uptake. Furthermore, low glycogen content prevents the additivity of
glucose uptake when insulin and contraction were combined. | en |
dc.description.abstract | Paper I: Tatt ut av filen i Brage p.g.a. copyright-restriksjoner. / Not in the file in Brage because of copyright issues. | |
dc.description.abstract | Paper II: Tatt ut av filen i Brage p.g.a. copyright-restriksjoner. / Not in the file in Brage because of copyright issues. | |
dc.description.abstract | Paper III: Tatt ut av filen i Brage p.g.a. copyright-restriksjoner. / Not in the file in Brage because of copyright issues. | |
dc.description.abstract | Paper IV: Lai YC, Lin FC & Jensen J (2009). Glycogen content regulates insulin- but not
contraction-mediated glycogen synthase activation in the rat slow-twitch soleus
muscles. Acta Physiol. 197(2): 139-150. | |
dc.format.extent | 1338118 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | en |
dc.subject | muskler | |
dc.subject | metabolisme | |
dc.subject | diabetes | |
dc.subject | forebygging | |
dc.subject | glykogen | |
dc.subject | blodsukker | |
dc.subject | fysisk aktivitet | |
dc.title | Role of glycogen content on glucose uptake and glycogen synthase in skeletal muscles: The effect of contraction and insulin | en |
dc.type | Doctoral thesis | en |
dc.subject.nsi | VDP::Mathematics and natural science: 400::Basic biosciences: 470 | en |
dc.subject.nsi | VDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710 | en |