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dc.contributor.authorLai, Yu-Chiang
dc.date.accessioned2010-04-12T11:15:14Z
dc.date.issued2010-04
dc.identifierSeksjon for fysisk prestasjonsevne / Department of Physical Performance
dc.identifier.isbn978-82-502-0436-2
dc.identifier.urihttp://hdl.handle.net/11250/171297
dc.descriptionAvhandling (doktorgrad) – Norges idrettshøgskole, 2010.en
dc.description.abstractThe present thesis is based on 4 papers which have investigated contraction- and insulin-mediated regulations of glucose uptake and GS activation in skeletal muscles with different glycogen contents. The level of glycogen content in skeletal muscle has a strong effect on the regulation of glucose metabolism. In the present thesis, we have shown that low glycogen content strongly increased glucose uptake in epitrochlearis muscle either under insulin and contraction stimulation alone or in combination. GLUT4 content was increased in epitrochlearis muscle with low glycogen content which can contribute the increased glucose uptake. Although insulin-stimulated PKB phosphorylation and contraction-stimulated AMPK activation were highest in muscle with low glycogen content, AS160/TBC1D1 phosphorylation was not elevated correspondingly, suggesting that these key signalling molecules do not determine the rate of glucose uptake. Furthermore, low glycogen content prevents the additivity of glucose uptake when insulin and contraction were combined.en
dc.description.abstractPaper I: Tatt ut av filen i Brage p.g.a. copyright-restriksjoner. / Not in the file in Brage because of copyright issues.
dc.description.abstractPaper II: Tatt ut av filen i Brage p.g.a. copyright-restriksjoner. / Not in the file in Brage because of copyright issues.
dc.description.abstractPaper III: Tatt ut av filen i Brage p.g.a. copyright-restriksjoner. / Not in the file in Brage because of copyright issues.
dc.description.abstractPaper IV: Lai YC, Lin FC & Jensen J (2009). Glycogen content regulates insulin- but not contraction-mediated glycogen synthase activation in the rat slow-twitch soleus muscles. Acta Physiol. 197(2): 139-150.
dc.format.extent1338118 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoengen
dc.subjectmuskler
dc.subjectmetabolisme
dc.subjectdiabetes
dc.subjectforebygging
dc.subjectglykogen
dc.subjectblodsukker
dc.subjectfysisk aktivitet
dc.titleRole of glycogen content on glucose uptake and glycogen synthase in skeletal muscles: The effect of contraction and insulinen
dc.typeDoctoral thesisen
dc.subject.nsiVDP::Mathematics and natural science: 400::Basic biosciences: 470en
dc.subject.nsiVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en


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